↓  Product Catalog  Anti-ERBB2 (Trastuzumab)-Mc-MMAE (Thiol MMAE) ADC USA
Price $ 1.00 Minimum Order 1
Location 45-1 Ramsey Road, Shirley, NY 11967, US Shipping Cost $ 1.00
Posted On 12/06/2017, 09:55:50 AM Sample Available No
Posted By Creative Biolabs [ Gold ] Product Status New
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https://www.creative-biolabs.com/adc/target-erbb2-37.htm This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a Mc linker to a MMAE (Thiol MMAE). The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.