↓  Product Catalog  Anti-ERBB2 (Trastuzumab)-bisAlk-VC-MMAE ADC USA
 
Price $ 1.00 Minimum Order 1
Location 45-1 Ramsey Road, Shirley, NY 11967, US Shipping Cost $ 1.00
Posted On 12/07/2017, 10:18:32 AM Sample Available No
Posted By Creative Biolabs [ Gold ] Product Status New
Payment Mode Credit Card
Categories Home > Chemicals
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  Description  
https://www.creative-biolabs.com/adc/target-erbb2-37.htm This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a bisAlk-VC linker to a MMAE. The MMAE is targeted to breast cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood. Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.